LYSOCIL Interest Group sessions

The LYSOCIL project has relaunched the LYSOCIL Interest Group sessions. The main goal of these sessions is the promotion and discussion of themes related with the biology and the functions of the lysosome in the cellular physiology and pathology. These sessions are also presented mainly by Master, PhD students and Postdocs allowing early stage researchers to present and discuss their results with senior researchers.

The first session was held on 5th June 2020 via Zoom and it was presented by Susana Lopes, Group Leader at CEDOC-NMS I FCM. The session was dedicated to Time for breaking left-right symmetry. The LYSOCIL group led by Susana Lopes has shown new results on the development of left-right early establishment by using a new technical approach that allowed for new discoveries. They can extract picoliter amounts of the fluid inside the left-right organizer and demonstrate that this transient organ has a sensitive time-window for performing its developmental function. The multidisciplinary study is part of the PhD of Pedro Sampaio and is now being prepared for submission with the collaboration of mathematicians and physicists.

The second session was held on 3rd July 2020 also via Zoom and it was presented by Luísa Lemos, Postdoc from Miguel Seabra group (CEDOC-NMS I FCM). The session was dedicated to Modelling retinal degenerative diseases using 3D retinal organoids. Three-dimensional (3D) retinal organoids derived from human induced-pluripotent cells (iPSCs), recapitulate the cellular organization and the light sensitivity of the human retina. The group recently implemented this cell culture model that resemble the complexity of the retinal tissue. The group is currently exploring the co-culture model of 3D organoids and retinal pigmented epithelium (RPE) cells as a model to study diseases involving lysosomal dysfunction that lead of vision loss and blindness.