Second LIG session dedicated to 'Modelling retinal degenerative diseases using 3D retinal organoids'
The second LIG session was held on 3rd July 2020 avia Zoom and it was presented by Luísa Lemos, Postdoc from Miguel Seabra group (CEDOC-NMS I FCM). The session was dedicated to 'Modelling retinal degenerative diseases using 3D retinal organoids'. Three-dimensional (3D) retinal organoids derived from human induced-pluripotent cells (iPSCs), recapitulate the cellular organization and the light sensitivity of the human retina. The group recently implemented this cell culture model that resemble the complexity of the retinal tissue. The group is currently exploring the co-culture model of 3D organoids and retinal pigmented epithelium (RPE) cells as a model to study diseases involving lysosomal dysfunction that lead of vision loss and blindness.