Honorable Mention Award of the contest “Science on Stage at the University” - video “escleROdeRmiA: when RARE is not obvious”

July 29, 2021


Congratulations for the Honorable Mention Award in the contest “Science on Stage at the University” to the group of students Liliana Lopes, Andreia Teixeira Ferreira, Tatiana Burrinha and Jorge Borbinha from CEDOC - NOVA Medical School with the video “escleROdeRmiA: when RARE is not obvious”


“Science on Stage at the University” is an initiative that aims to rise the interest of students at NOVA Medical School - Faculty of Medical Sciences and their awareness of rare diseases.




LYSOCIL CEDOC-NMS I FCM special seminar with Professor Stephen King

July 28, 2021 @Zoom


Special LYSOCIL CEDOC-NMS I FCM seminar with Professor Stephen King from the Department of Molecular Biology and Biophysics, University of Connecticut Health Center (USA) will take place on July 28, 2021 at 16:00, via Zoom. This seminar will be dedicated to “Peptide Amidation, Ciliogenesis and Cilia-based Peptidergic Signaling”. Please request the link to: manage.lysocil@nms.unl.pt


Title: Peptide Amidation, Ciliogenesis and Cilia-based Peptidergic Signaling


Abstract: Cilia are sensory and secretory organelles that both receive information from the environment and transmit signals. Peptidergic signaling is an ancient process found throughout the metazoa that regulates a wide range of physiological and behavioral responses in vertebrates.  Many peptides require C-terminal amidation for bioactivity.  We identified the peptide amidating enzyme, peptidylglycine α-amidating monooxygenase (PAM), in cilia and found that it plays a key role in ciliogenesis in the unicellular green alga Chlamydomonas reinhardtii, planaria and vertebrates (mice and zebrafish). Cilia derived vesicles (ectosomes), formed by outward budding of the ciliary membrane, carry information and play vital roles in intercellular communication. We have now identified the developmentally regulated release of PAM, its bioactive amidated products and other components of the peptidergic signaling machinery specifically in ciliary ectosomes from mating Chlamydomonas gametes. One identified amidated peptide product in ciliary ectosomes (termed GATI-amide) serves as a chemotactic modulator for Chlamydomonas gametes.  To understand the processing pathway leading to formation of the GATI-amide product, we generated antibodies against synthetic peptides from the N-terminal and C-terminal regions of the full length of GATI-amide precursor (Cre03.g204500) and purified them on peptide affinity columns.  The antibody against the C-terminal region is amidation specific. Using these antibodies, we found that multiple forms of Cre03.g204500 (~250, 120, 75 and 63 kDa) are released in ciliary ectosomes and that the 75-kDa amidated product is present in both ectosomes and gamete cell lysates. This 75-kDa amidated product is found in the cilia of plus gametes but not in those of minus gametes before mating-induced release of ciliary ectosomes.  Immunogold-EM analysis using antibodies to the N- or the C-terminal region of Cre03.g204500 localized both epitopes to the surface of intact ectosome. Thus, cilia provide a route for the secretion of amidated signaling peptides. Our study in Chlamydomonas and the presence of PAM in mammalian cilia suggest that ciliary ectosome-mediated peptidergic signaling dates to the early eukaryotes and may play key roles in metazoan physiology.





Winning video of the contest “Science on Stage at the University” - “The art of being rare”

July 26, 2021


It is with great pleasure that LYSOCIL announce the winning group of the contest “Science on Stage at the University” made up of the students of Nutrition and Medicine Sciences at NOVA Medical School - Faculty of Medical Sciences – Ana Teresa Leitão, Ana Sofia Faria and Ana Sofia Gaspar.

Congratulations to the winners for the video “The art of being rare”.


The “Science on Stage at the University” is an initiative that aims to increase the interest of students at NOVA Medical School - Faculty of Medical Sciences and their awareness of rare diseases.


The prize for this contest consists of: 

• 1 week integration in a CEDOC-NMS I FCM-UNL laboratory

• 3 days of exchange at the Telethon Institute of Genetics and Medicine (TIGEM), prestigious Research Institute, near Naples, Italy.

• The expected date for these exchanges is September 2021.



“Science on Stage at the University” Rare Diseases

9 July 2021 @zoom


Please note that this event is described in Portuguese.

The “Science on Stage at the University” is an initiative that aims to arouse the interest of students at NOVA Medical School - Faculty of Medical Sciences and their awareness of #rare diseases.


Come and watch the playback theater performance by the DISPAr Teatro group, which will take place on July 9, 2021, at 18:00, via Zoom.


dISPAr Theater is the theater group of ISPA - University Institute of Psychological, Social and Life Sciences, founded in 2005, which privileges theater as a place of research, search and meeting, exploring the approximations between theater and psychology .


During 1h30 you will be surprised by an improvised representation of true stories narrated in the first person where sharing experiences about rare diseases will be the motto for an artistic representation.


At the end, you can be awarded with the possibility of knowing the research work of a CEDOC laboratory (for a week) and having a three-day exchange at the Telethon Institute of Genetics and Medicine (TIGEM), a prestigious institute of biomedical research in Italy.


Registration: Participation in this initiative is free but requires prior registration.


Link for registration: https://lnkd.in/dbQeZip




Flyer_CienciaCenanaUniversidade_2021



Rare Disease