LYSOCIL Seminar with Duarte Barral at TIGEM

November 30, 2021


On the 30th November at 12 pm (Italy time) we will have a special online LYSOCIL Seminar with Duarte Barral, PhD, Associate Professor from Chronic Diseases Research Center (CEDOC), NOVA Medical School (PT) and LYSOCIL Coordinator. Please contact us to obtain the link to attend the seminar: manage.lysocil@nms.unl.pt


This seminar is organized under the scope of the LYSOCIL Drug Screening Workshop that is being held at TIGEM facilities these days. 


Title: “Deciphering the Molecular Mechanisms of Skin Pigmentation” 


Host researcher at TIGEM: Leopoldo Staiano


Abstract: Skin color is determined by the pigment melanin, which protects skin cells against ultra-violet radiation (UVr). Melanin is produced and stored in specialized organelles termed melanosomes, within melanocytes and then transferred to keratinocytes, where it exerts its photoprotective effect against UVr-induced damage, photo-aging and skin cancer. Therefore, skin pigmentation relies on the crosstalk between melanocytes, the pigment producers and keratinocytes, the pigment recipients. Melanosomes share several features with lysosomes, like low pH, the presence of lysosomal membrane proteins and catalytic enzymes, and are thus considered lysosome-related organelles. Melanosome biogenesis is initiated at the perinuclear region, whereas mature melanosomes accumulate at the tips of melanocyte dendrites. Once there, melanosomes are secreted from melanocytes and transferred to keratinocytes. The evidence collected by us over recent years strongly suggests that the predominant form of melanin transfer is via coupled exo/phagocytosis, where melanocytes exocytose the melanin core, or melanocore in a process dependent on the small GTPase Rab11b and the exocyst tethering complex. Moreover, we found that melanocore internalization by keratinocytes occurs through phagocytosis in a Protease-activated receptor (PAR)-2-dependent manner. Furthermore, we and others reported that upon internalization by keratinocytes, melanocores accumulate in moderately acidic and degradative compartments, which can explain why melanin is long-lived within these cells. In this seminar, I will also present recent unpublished data on the role of lysosomes and autophagy in melanin processing within keratinocytes.



Science & Technology Week 2021

November 23, 2021


On the 23th of November CEDOC-NMS I UNL researchers from LYSOCIL project participated on the Science & Technology Week, an outreach event organized by Ciência Viva. 

Duarte Barral, Susana Lopes, Cláudia Almeida, Diogo Bitoque from Gabriela Silva Lab, Sandra Tenreiro from Miguel Seabra Lab and Catarina M. Carvalho from Paulo Pereira Lab hosted at their lab facilities local secondary school’s students explaining their research and raising awareness in RD. 

Learn more at: http://cedoc.unl.pt/outreach-society/semana-da-ciencia-e-tecnologia-cedoc/



LYSOCIL Summer School 2021

November 8, 2021


The LYSOCIL Summer School will take place between 8th - 12th November 2021 at CEDOC facilities. This event relies mainly on hands-on sessions with practical components. The participants will gain theoretical knowledge and will be introduced to protocols and scientific methods related to lysosome and cilia biology, as well as being assisted to solve specific problems. We will have fun science mini-projects around lysosomes and cilia research topics. It will count with a renowned panel of experts.

Registration: This is a free event but registration is needed. Please register HERE

Deadline: 3rd November 2021

The Agenda will be sent after your registration.

We invite you all to participate!


Poster Summer School 2021


LYSOCIL Summer School lab work abstracts


[Schedule] - Summer School



Staff Exchange on "Genotyping for identifying genes that cause ciliopathies"

November 3, 2021


The LYSOCIL Staff Exchange 8 - Genotyping for identifying genes that cause ciliopathies will be held from 3th to 5th November 2021 at CEDOC-NMS facilities.

Bernd Dworniczak & Petra Pennekamp experts from University of Münster will provide training on genotyping for identifying genes that cause ciliopathies. One expert will provide training in the technological set up and the definition of the analysis strategy (panel vs WES vs WGS vs transcriptome and establishment of targeted panels), including the difficult cases; and the other one will introduce novel bioinformatic tools.

Registration: This is a free event but registration is needed. Please register HERE

Deadline: 2nd November 2021

The Agenda will be sent after your registration.

We invite you all to participate!


PosterSE8GenotypingCiliopathies


[Schedule] - Staff Exchange 8 - "Genotyping for identifying genes that cause ciliopathies"



Rare Disease