The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases
This study describes the first evidence that a component of the intraflagellar transport complexes, responsible for the formation and maintenance of cilia and flagella, is implicated in the biogenesis of lysosomes.
Rab3a and Rab10 are regulators of lysosome exocytosis and plasma membrane repair
Disruption of the cell plasma membrane can occur for various reasons and its repair is essential to guarantee the cell survives. The proteins Rab3a and Rab10 and their interactions with other proteins, have been found to have an essential role in lysosome exocytosis and plasma membrane repair.
A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair
Lysosome exocytosis plays a major role in fixing disruptions of the plasma membrane. This study shows the importance of Rab3a, a protein of the Rab family, in this process. It also reports the identification of a new protein that interacts with Rab3, with consequences in lysosome positioning and exocytosis.